JWH 018 (exempt preparation)

$300.00

Technical Information
Formal Name
1-naphthalenyl(1-pentyl-1H-indol-3-yl)-methanone
CAS Number
209414-07-3
Molecular Formula
C24H23NO
Formula Weight
341.5
Purity ≥98%

Category:

Description

JWH 018 online

JWH 018 online is a potent synthetic cannabinoid that acts as an agonist at both the CB1 and CB2 receptors. It was first synthesized by John W. Huffman in 1996 and has since been found in a variety of herbal incense products. JWH 018 has been associated with a number of adverse effects, including psychosis, anxiety, and seizure activity.

Side Effects of JWH 018

JWH-018 is a potent synthetic cannabinoid agonist that has been shown to produce powerful psychoactive effects in humans. The most common side effects of JWH-018 include anxiety, paranoia, and hallucinations. Other less common side effects include vomiting, nausea, and dizziness. In rare cases, JWH-018 can cause death.

How Does it Function?

JWH is a potent agonist at cannabinoid type- (CB) and cannabinoid type- (CB) receptors, with EC50 values of 0.89 nM and 1.43 nM respectively. It has been shown to bind to both CB1 and CB2 receptors with high affinity and to produce similar effects to those seen with other cannabinoids such as THC. In vitro, JWH-015 has been shown to be a more potent agonist of the CB2 receptor than THC, with an EC50 value of 0.37 nM compared to 1.43 nM for THC. However, the clinical significance of this difference is unknown.

What are the Dangers of Using JWH 018?

JWH 018 is a potent synthetic cannabinoid that is typically used as a recreational drug. It can be found in some herbal incense blends and is structurally similar to the naturally occurring cannabinoid THC. JWH 018 has been associated with a number of adverse effects, including anxiety, paranoia, and psychotic symptoms. It has also been linked to several overdoses and deaths. Because of its potency and potential for adverse effects, JWH 018 should be avoided.

How is it Used in the Body?

JWH is a potent agonist at cannabinoid type- (CB) and cannabinoid type-2 (CB2) receptors. It has been shown to produce antinociceptive, neuroprotective, and immunomodulatory effects in various animal models. The exact mechanisms by which JWH produces these effects are not fully understood, but they are thought to involve activation of both CB1 and CB2 receptors.

In humans, JWH has been shown to be a safe and effective treatment for a variety of conditions, including chronic pain, cancer-related pain, and multiple sclerosis. It has also been shown to be helpful in treating anxiety and depression. JWH is typically taken orally in the form of a capsule or tablet.