4ACO-DMT also referred to as synthetic mushrooms, is a prodrug of the hallucinogenic substance in magic  mushrooms (psilocin). The experience is identical to magic mushrooms, with a few slight subjective differences. Since the long-held patents on this chemical have long since expired, plans by companies like Compass Pathways to dominate the synthetic psilocybin market for the foreseeable future are in jeopardy.

Describe 4ACO-DMT:

4-Acetoxy-DMT is the abbreviation for 4-AcO-DMT. Franz Troxler and Albert Hofmann, two of the guys who invented LSD, produced it (lysergic acid diethylamide). It was developed in the 1960s due to the two’s research on the psychoactive elements in psychedelic mushrooms.

4aco-dmt is a derivative of psilocin, the primary pharmacological component of magic mushrooms. The liver converts psilocybin and 4-AcO-DMT into psilocin, which has psychedelic properties. As a result, psilocybin or psilocin and 4-AcO-effects DMTs are very similar.

The Sandoz company employed the team, which submitted a patent in January 1963 but never permitted it to be used for profit. Simply put, they had no idea how to handle this psychoactive substance or any other Hofmann-produced substance (including LSD and psilocybin). This occurred shortly after the Harvard Psilocybin Project, which Timothy Leary and Richard Alpert led. Sandoz gave Leary a lot of LSD so he could research it and explore potentially profitable applications in psychotherapy.

4-AcO-DMT was disregarded for many years until the late 1990s when a guy named David E. Nichols began promoting its usage in psychedelic-assisted psychotherapy. For this material to eventually be used in medicine, he intended to motivate scientists to explore it further. Because of its effectiveness, accessibility, and predictability of outcomes, Nichols complimented it. Sadly, no clinical study has examined the effects of 4aco-dmt. The vast majority of knowledge now available comes from studies on animals and anecdotal accounts.

A more popular synthetic psychedelic than 2C-B, Dipt, and other members of the 2C-X family but less thoroughly researched than LSD and ketamine is 4-AcO-DMT. 4aco-dmtis often sold as a yellowish-brown powder in capsule or tablet form in its untreated state.

How does 4-AcO-DMT make you feel?

4-AcO-DMT mimics the effects of psilocybin mushrooms. Psilocin, the primary metabolite of 4-AcO-DMT, is the active ingredient. As a result, the hallucinogen psilocin, found in nature, is a prodrug of 4acodmt. At lower doses, 4aco-dmt and magic mushrooms are nearly equivalent (up to 30 mg). It alters the perception of time and sensory input, enhances existential and introspective thought processes, suppresses the default mode network (DMN), and produces aural and visual hallucinations.

With higher doses, 4aco-dmt effects start to change (above 30 mg). This dosage is more akin to DMT and is fairly strong. The images get much more fractal and geometric while the hallucinations, empathy, and introspection worsen. The existential weight of the substance, especially in higher doses, is one of the main reasons, so many people only use this drug once. It is unknown why high doses of 4aco-dmt are far more probable than high doses of magic mushrooms to cause spooky or unpleasant trips. From our trip surveys, we have 11 reports of people using 4-AcO-DMT. Most consumers took between 20 and 30 mg, describing effects that were comparable to magic mushrooms but slightly more subdued.

Common 4AcO-DMT Side Effects:

  • Time perception was changed via introspection.
  • Fractal geometric patterns
  • People’s perceptions of music can alter, occasionally for the better.
  • Body floating sensation
  • Euphoria
  • Ego-dissociation

What is the duration of 4-acO-DMT?

This medication lasts between two and six hours. It doesn’t usually last for the full eight hours, just like magic mushrooms. If you ingest 4-AcO-DMT on an empty stomach or inhale the powder rather than taking it as a capsule, the effects will begin and end sooner.

For instance, if you take 4-AcO-DMT as a capsule, you should give it up to 45 minutes to start working. The peak experience lasts for around two hours before progressively fading away for the next two to four hours. The effects of insufflating (snorting) the powder start to take effect after about 15 minutes, peak after an hour, and then taper off throughout the following two to three hours.

What dosage of 4-AcO-DMT is there?

One of the advantages of 4-AcO-key DMT and the reason supporters like David Nicoles are so enthused about it is the consistency of its effects. This pure molecule’s quick and predictable metabolism makes it much easier to gauge the effects’ strength than with more organic psychedelics. Plants and fungi are trickier to dose since the concentration of the active ingredients might vary substantially from sample to sample.

The usual dosage of 4-AcO-DMT ranges from 10 to 30 mg. Some people only take a microdose, while others take the whole dosage (heroic Dose). Twenty milligrams is roughly equivalent to 3 grams of dried psilocybin mushrooms in terms of dosage. It is preferable to start at the low end of the spectrum and gradually work your way up while using 4-AcO-DMT for the first time. The type of 4-AcO-DMT use has a minimal impact on the Dose. For instance, if you were using 4-AcO-DMT fumarate salt, you would need about 1.24 mg of powder. If you’re using 4-AcO-DMT in salt form, you need 1.15 mg of powder. Furthermore, the Dose is around 20% lower when the active ingredients are inhaled as opposed to taken orally.

Here are some general dosage guidelines to get you started:

  • A microdose is 1-2 mg.
  • The threshold dose of 5 mg
  • 10–20 mg as a small dose
  • Common Dose: 20–30 mg
  • 40+ mg Herculean Dose

How Does 4-AcO-DMT Compare to Other Psychedelics?

Despite having similarities to LSD, N, N, DMT, and 5-MeO-DMT, as well as other indole alkaloids, 4-AcO-DMT is most analogous to psilocybin and psilocin. Its homologs include the psychoactive research chemicals 4-AcO-MET, 4-AcO-DET, 4-AcO-MiPT, and 4-AcO-DiPT.

Psilocybin VS 4ACO-DMT:

Another name for 4-AcO-DMT is synthetic mushrooms. This is true because the body processes 4-AcO-DMT in the same way that it does magic mushroom active ingredients. When 5-HT2A is converted to psilocin, the brain’s 5-HT2A receptors cause the psychedelic effect.

4-AcO-DMT is a derivative of psilocybin (4-PO-DMT) and psilocin (4-HO-DMT). Since magic mushrooms and even synthetic psilocybin have more similarities than differences, most users won’t be able to tell the difference between the 4-AcO-DMT experience and either of these. There are a few slight differences between these compounds, though.

For instance, 4-AcO-DMT is more mellow than magic mushrooms when taken at smaller doses. It is more collected, thoughtful, and acute. Magic mushrooms frequently bring on fuzzy feelings. Decision-making can be difficult, and vision may need to be more clear. This is less visible when using 4-AcO-DMT. Another point of difference is the onset times. When taken orally or while fasting, 4-AcO-DMT starts working almost immediately. In contrast to 4-AcO-DMT, the effects of magic mushrooms can take up to an hour or more to take effect.

When utilizing 4-AcO-DMT, nausea, a common adverse effect of magic mushrooms, is far less likely. The most likely explanation is that 4-AcO-DMT lacks chitin or other fibers found in magic mushrooms that could irritate the gut lining. At higher doses, 4-AcO-DMT starts to distinguish itself from magic mushrooms. When consumed in big doses, the effects are more similar to DMT (above 40 mg). It produces powerful fractal and geometric hallucinations and profound existential “realizations,” even more so than large doses of magic mushrooms.

5-MeO-DMT Against 4ACO-DMT:

5-MeO-DMT, a hallucinogen secreted by the Bufo alvarius toad, shares a striking structural similarity with 4-AcO-DMT. ThereforeBoth, compounds stimulate the 5-HT2A receptors, and the results are the same. Still, the strength of the sensation is significantly different. The hallucinogenic effects of synthetic mushrooms are comparable to those of magic mushrooms, LSD, 2-CB, and LSA. It can modify how we interpret sensory information, change how we perceive time and space, and subject the mind to more entropy. These meetings trigger mystical experiences and existential insights influenced by increased entropy.

5-MeO-DMT, in contrast, operates at a higher level. Attempting to express how powerful and singular this experience is is nearly difficult. Users frequently encounter entirely out-of-body situations where they are cut off from reality and their familiar surroundings. The other important distinction is the duration. 5-MeO-DMT only lasts 15 to 30 minutes, whereas 4-AcO-DMT frequently lasts up to 6 hours.


LSD or its equivalents and 4-AcO-DMT have similar effects, but each has unique characteristics. Compared to LSD (Lysergic Acid Diethylamide), 4-AcO-DMT is said to be “more grounded” and to produce a more physical high. Both drugs target the same receptors, albeit at different ratios of binding strength. The main target is the 5HT2A receptors, which are in charge of most psychedelic effects.

Online retailers regularly provide 4-AcO-DMT packaged with 1P-LSD (especially in Canada, where both compounds are legal). Like how 1P-LSD is the prodrug for LSD, and 4-AcO-DMT is the prodrug for psilocybin. Also favorably compared are the LSD derivatives PRO-LAD, AL-LAD, LSZ, ETH-LAD, and ALD-52.

The safety of 4-AcO-DMT:

4-AcO-DMT has a remarkable safety record. Compared to the majority of indole alkaloids, psilocybin, psilocin, LSD, DMT, and LSA have comparatively few negative effects on the body, even at large dosages. The safety properties of each of these compounds have been thoroughly tested. The use of 4-AcO-DMT alone has never been linked to a fatality. Several fatalities have been connected to other medications. As with any psychedelic chemical, there is some possibility of psychological harm from utilizing this substance. Usage of 4-AcO-DMT may contribute to or hasten psychotic breakdowns.

Full psychedelic experiences can cause an ontological shock if the person is unprepared or has the tools to handle them well. This could lead to long-term psychological suffering, such as post-traumatic stress disorder (PTSD), sadness, and anxiety. The biggest safety issues with this medicine are Dose and adulteration with potentially dangerous compounds like fentanyl, PCP, or NBOMe because it is easy to take too much of it. Since it’s a chemical powder, it’s easier to contaminate harmful substances. Always do a test on your 4-ACO-DMT before assuming it is pure.

Always check your medications with a drug testing kit. I enjoy using the kits from Elevation Chemicals for this. When handling liquids or powders, reagent test kits are essential for responsible substance use. Any substance you take that isn’t a raw plant or fungus should always be tested to ensure it is what you think it is.

Please be advised that reagent testing can only identify the types of compounds present; it cannot assess the sample’s purity. This does not guarantee the sample’s complete safety; it is a step toward harm reduction. For testing, just a tiny quantity of your medication is required, and the testing reagents are reasonably priced. A drop and a sample the size of a sand grain are needed for each test. Consumer safety may be ensured quickly, affordably, and effectively through testing.

In an ideal situation, four tests using the Ehrlich, Marquis, Mecke, and Mandelin reagents would be carried out to test 4-AcO-DMT. Each one looks at a different chemical. If money were tight, the most important test would be the Ehrlich reagent, which is used to identify indole alkaloids. If it fails this test, which means it doesn’t turn purple, the substance you have is not 4-AcO-DMT, and you should never use it.

Place a small sample on a white ceramic or plastic surface to perform the test. The sample should resemble a salt particle in size. Once the sample has been exposed to one drop of the test reagent, watch how long it takes for the sample to change color. Wait three minutes for the reaction to complete before noting the hue.

4-AcO-DMT side effects include:

4-AcO has a high potency when concentrated. The powder just only a few milligrams to produce a considerable dose, as opposed to mushrooms, which need many grams to generate the right Dose. If you take more than a few mg of magic mushrooms, the effects won’t change. A small increase in 4-AcO-DMT dosage can significantly impact the experience. Lower doses of 4-AcO-DMT are more likely to result in a more challenging trip than one that is calming and uplifting. Because of this, 4-AcO-DMT rarely has undesirable bodily effects.

The following 4-AcO-DMT side effects could occur:

  • Health and vomiting
  • Dizziness
  • Anxiety
  • Paranoia
  • Heart skips a beat
  • Headaches
  • The chest is flushed, as is the face.

Is 4-AcO-DMT permitted?

Most regions of the world are in legal limbo regarding 4-AcO-DMT. Regulators mostly overlooked it, and neither the UN Convention on Psychotropic Substances nor the United States nor Canada’s lists of prohibited substances officially include it by name. This substance is freely available online and is legally permissible in Canada.

In the United States, things are a little bit different. Despite not being known, 4-AcO-DMT is an illegal psilocin analog. Although it is unlikely that anyone will be detained for having 4-AcO-DMT, the Federal Analogue Act technically classifies it as a Schedule I drug. It is, therefore, possible that 4-AcO-DMT has been categorized as a Class A substance in the UK under the Misuse of Drugs Act of 1971. Since 4-AcO-DMT is listed as a Schedule 9 substance in Australia, we are only permitted to sell it with the purchaser’s consent. We haven’t seen any evidence of 4-AcO-DMT being lawfully sourced in Australia, and it doesn’t seem like they’re granting licenses for it, either.

How 4-AcO-DMT Works Like most indole psychedelic alkaloids, 4-AcO binds to the 5-HT2A serotonin receptors. These receptors are thought to suppress the brain’s Default Mode Network (DMN). This network is in charge of controlling how information moves between different parts of the brain. It performs the role of a reducing valve, limiting the information that reaches the brain and obstructing some mental processes. With the help of this approach, we should work more efficiently and avoid becoming stressed at insignificant events.

The reduction valve is left wide open when psychedelics like 4-AcO-DMT block the DMN. The brain can therefore react to introspective thoughts and sensory awareness to a far greater extent. This state alters our perception of time and sensory information, enhances our capacity for original thought and creativity, and awakens memories and emotions that the brain would typically suppress. We thus encounter visual and aural hallucinations, an intensely reflective condition, ego death, dissolution, and a strong sense of connectedness to the outside world.

The majority of indole and phenethylamine psychedelics bring on this sensation. These chemicals target the same receptors to create their effects while having different affinities for other serotonin receptors, NMDA receptors, GABA, and many other receptors. This explains why psychedelic effects vary so much, even though they all fundamentally accomplish the same task.

Questions and Answers Regarding 4-AcO-DMT:

Despite being in use since the 1960s, there are still a lot of mysteries surrounding 4-AcO-DMT. There has not yet been high-quality clinical research on this substance’s potential use in psychotherapy or treating conditions like cluster headaches or anxiety. These two psilocybin uses have already demonstrated significant promise. However, the following are some of the most often questions we get asked by 4-AcO-DMT consumers about its usage:

What color should the 4-AcO-DMT be?

4-AcO-DMT comes in two different basic forms, each of which has a unique color. 4-AcO-DMT hydrochloride is a yellowish-brown powder. At times the powder is as fine as flour, and at other times crystals may develop. Although it is normally a little darker, the salt form of 4ACO-DMT fumarate is also a light brown color. Color is not a strong indicator of purity on its own. A reagent test kit will be needed for this. If you detect dark brown, black, or pure white granules, you should be very careful and inspect the object before utilizing it.

Does Your Home Produce 4-AcO-DMT?

Technically, you can make 4-AcO-DMT with a few common lab reagents and tools. It is strongly advised that you leave this to the professionals nevertheless. Although it is not very difficult to make 4ACO-DMT and related compounds, numerous potential reaction mistakes could lead to harmful byproducts. Additionally, it is typically illegal in most countries. There is some information available if you’re interested in finding out how to manufacture 4ACO-DMT.

Where do I find 4ACO-DMT for sale?

If you reside in the US, you are still looking for a way to get through. Since this chemical is illegal in the US, it cannot be purchased from reliable sources. Even though buying it from street vendors is against the law, the products may be contaminated or adulterated. In particular, we advise against obtaining 4ACO-DMT. If you live in Canada, you can purchase this chemical legally from companies like ChemLogix. It is highly cost-effective, costing about $25 for four regular dosages (25 mg each).

The Future of 4ACO-DMT:

Even though4aco-dmt has been available for some time, it wasn’t well known until about ten years ago. Since then, the market has seen a surge in demand for this substance, making it one of the most accessible synthetic psychedelics.

We expect that interest in 4aco-dmt will continue to rise throughout the next years. Psilocin or Psilocybin is currently being produced synthetically by several companies; however, most try to patent the completed product. They will be able to increase the cost of the good and establish a monopoly over its management. Since 4-AcO-patent DMT’s protection has already ended, it is no longer in the public domain. This suggests that the substance will always be affordable, despite the entry of more enterprises and the legalization of psychedelic drugs.

This hallucinogenic is simple to prepare, has all the same benefits and sensations as magic mushrooms, and has added advantages in dosage homogeneity. 20 mg of 4aco-dmt will always result in effects of the same intensity, even though repeated doses of magic mushrooms, depending on the particular fungus used, could create a wide variety of intensities. Regarding psychedelic-assisted psychotherapy, 4-AcO-DMT is the better option because of its much more controlled effects.